Award
National Institute of General Medical Sciences 5R35GM136128-07
Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism
Recipient
Rutgers, The State University of New Jersey
Award Amount
$431,750.00
Ceiling
$431,750.00
Awarded
May 20, 2026
Identifier
5R35GM136128-07
This award funds research on the regulation and role of phosphatidate phosphatase in lipid metabolism, investigating its enzymatic activity, cellular localization, and impact on metabolic diseases.
Description
The project focuses on the regulation and function of phosphatidate phosphatase (PAP), an enzyme conserved from yeast to humans, involved in lipid homeostasis. It explores the enzyme's role in dephosphorylating phosphatidate to diacylglycerol, impacting triacylglycerol and membrane phospholipid synthesis, gene regulation, and cellular growth. The research aims to understand the enzyme's regulation via phosphorylation/dephosphorylation, its translocation between cellular compartments, and its implications for metabolic diseases such as obesity, lipodystrophy, and diabetes.