Award
National Institute of Environmental Health Sciences 7R01ES035353-03
Suppression of progesterone receptor signaling by heavy metals promotes tamoxifen resistance and metastasis or ER+ breast cancer
Recipient
H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL, UNITED STATES
Award Amount
$480,442.00
Ceiling
$480,442.00
Awarded
July 11, 2025
Identifier
7R01ES035353-03
Research project funded by NIEHS to study the impact of heavy metal exposure on breast cancer treatment resistance and to develop ROS scavenger-based therapies to improve outcomes and reduce health disparities.
Description
This project investigates how exposure to heavy metal pollutants like arsenic and lead promotes the emergence of breast tumor cells lacking progesterone receptor expression, leading to treatment resistance and metastasis in ER+/PR+ breast cancer. It aims to test organelle-targeted ROS scavengers as adjuvant therapeutics to restore treatment efficacy and mitigate health disparities affecting low-income and minority breast cancer patients.