Award
Washington State Department of Veterans Affairs 5I01BX004063-08
Mechanisms and Impact of Islet Vascular Inflammation in Diabetes
Recipient
VA PUGET SOUND HEALTHCARE SYSTEM, SEATTLE, WA, UNITED STATES
Awarded
July 30, 2026
Identifier
5I01BX004063-08
Research project funded by the Veterans Affairs to study islet vascular inflammation in diabetes, specifically the effects of hIAPP aggregation on islet endothelial cells and β-cell dysfunction, with the goal of developing targeted therapies for type 2 diabetes.
Description
This project investigates the mechanisms and impact of islet vascular inflammation in diabetes, focusing on the role of human islet amyloid polypeptide (hIAPP) aggregation in islet vasculopathy and its effects on insulin release and β-cell function. The study aims to develop new vascular-targeted therapies for β-cell dysfunction in type 2 diabetes by exploring islet endothelial cell-pericyte interactions and their disruption.