Award
NIH Reporter #1F31CA317811-01
Understanding the Role of Tonic TCR Signaling to Optimize CAR-T Efficacy
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$38,741.00
Ceiling
$38,741.00
Awarded
August 05, 2026
Identifier
1F31CA317811-01
Research project to optimize CAR-T cell therapy efficacy by studying tonic TCR signaling and the role of CD5 in CAR T cell survival and function.
Description
This research aims to understand how natural T cell signals, particularly tonic TCR signaling marked by CD5 expression, influence CAR T cell survival, proliferation, exhaustion resistance, and metabolic fitness. The goal is to define the relationship between tonic TCR signaling strength and CAR T cell efficacy, and to determine whether CD5 plays a mechanistic role in this process, ultimately leading to improved CAR T cell therapies.