Award
NIH Reporter #1R21AI191151-01
Protease sensor for rapid and sensitive detection of Borrelia infections
Recipient
Not Specified
Award Amount
$436,236.00
Ceiling
$436,236.00
Awarded
July 28, 2025
Identifier
1R21AI191151-01
Development of a biosensor to detect Borrelia infections causing Lyme Disease using a specific protease biomarker.
Description
This project aims to develop a highly sensitive biosensor to detect active Borrelia burgdorferi infections, the causative agent of Lyme Disease. The biosensor will target the Bb protease, high temperature requirement A (BbHtrA), as a biomarker. The device will utilize covalent probes attached to epitaxial graphene to detect the bacteria in blood, urine, and synovial fluid samples.