Award
National Institute of Allergy and Infectious Diseases 5R01AI124186-10
RNA-directed targeting of AID in immunity and cancer
Recipient
Sloan-Kettering Institute for Cancer Research, New York, NY, United States
Award Amount
$531,000.00
Ceiling
$531,000.00
Awarded
June 10, 2026
Identifier
5R01AI124186-10
Award for research on the targeting of AID in immunity and cancer, exploring DNA repair mechanisms and gene regulation in B cells to understand immunity and lymphoma development.
Description
This project investigates the role of activation induced cytidine deaminase (AID) in B cell immunity and cancer, focusing on mechanisms of DNA double strand breaks during class switch recombination and somatic hypermutation, and how AID regulates gene expression to influence B cell responses.