Award
NIH Reporter #1R03AI202471-01
Staphylococcus aureus Virulence Factor Heterogeneity in Neutrophils: Mechanisms and Consequences for Host-Pathogen Interactions
Recipient
Johns Hopkins University
Award Amount
$77,750.00
Ceiling
$77,750.00
Awarded
August 14, 2026
Identifier
1R03AI202471-01
This NIH grant supports research on the heterogeneity of Staphylococcus aureus virulence factor activity in neutrophils to understand host-pathogen interactions and develop targeted strategies against resilient bacterial subpopulations.
Description
The project investigates heterogeneity in the activity of the virulence regulator Sae in Staphylococcus aureus within neutrophils. The work aims to understand how differential Sae activity correlates with bacterial localization and fate. The project involves constructing fluorescent reporter strains and evaluating them in vitro and in vivo. The goal is to inform strategies to target resilient bacterial subpopulations.