Award
National Institute of Diabetes and Digestive and Kidney Diseases 4U24DK112349-08
ProMoTr: A Proteomics Center for MoTrPAC
Recipient
Battelle Pacific Northwest Laboratories
Award Amount
$1,349,999.00
Ceiling
$1,349,999.00
Awarded
July 10, 2025
Identifier
4U24DK112349-08
This award funds a proteomics center to study molecular mechanisms of physical activity benefits by analyzing protein changes and modifications in human tissues, supporting a consortium with advanced mass spectrometry workflows.
Description
The project aims to provide a comprehensive map of protein molecular transducers that transmit the health benefits of physical activity using high throughput proteomics technologies. It supports the consortium by discovering proteins and post-translational modifications in skeletal muscle and adipose tissues, focusing on intracellular signaling mediated by protein PTMs. The project involves multi-omics analysis, temporal profiling following exercise, proteomics profiling, coordination with other MoTrPAC activities, and dissemination of results.