Award
NIH Reporter #1R01AR083960-01A1
T-cell plasticity mediating treatment resistance and side effects in atopic dermatitis
Recipient
Icahn School of Medicine at Mount Sinai, NY
Award Amount
$528,558.00
Ceiling
$528,558.00
Awarded
August 08, 2025
Identifier
1R01AR083960-01A1
Research project funded by NIAMS to investigate immune mechanisms behind treatment resistance and side effects in atopic dermatitis patients treated with dupilumab, using advanced molecular techniques and patient biopsies to develop better therapies.
Description
This project aims to study treatment-resistant atopic dermatitis and paradoxical inflammatory skin side effects in patients treated with dupilumab to understand underlying mechanisms and develop better treatments. The study will analyze cellular and molecular features of the immune microenvironment in different skin lesion states using high-throughput techniques and characterize cytokine production and crosstalk with tissue microenvironment cells to create effective, stratified therapies for atopic dermatitis.