Award
National Institute of Mental Health 5R01MH137471-03
Characterization and Modulation of Functional Connectivity and Fear Extinction Abnormalities in Obsessive-Compulsive Disorder
Recipient
Yale University, New Haven, CT
Award Amount
$810,086.00
Ceiling
$810,086.00
Awarded
July 23, 2026
Identifier
5R01MH137471-03
The award funds research to understand and modulate brain network connectivity and fear extinction learning deficits in OCD patients, potentially improving treatment outcomes using neurostimulation techniques.
Description
This project aims to examine if OCD is associated with deficits in inhibitory safety learning and to test if frontopolar tDCS can normalize dysconnectivity and functional activity within and between the DMN and SN and recover safety learning deficits in patients with OCD. The research could lead to further studies on neural abnormalities and safety learning deficits in anxiety disorders and clinical trials on the effects of frontopolar tDCS and ERP.