Award
National Institute on Aging 3R21AG085428-01S2
DNA methylation signatures of Alzheimer's disease in aged astrocytes
Recipient
University of Texas at San Antonio
Award Amount
$41,228.00
Ceiling
$41,228.00
Awarded
December 10, 2024
Identifier
3R21AG085428-01S2
This award supports research to develop a novel in vitro model of aged human astrocytes to study DNA methylation and transcriptional changes linked to aging and Alzheimer's disease, aiming to understand disease mechanisms and guide therapeutic strategies.
Description
The research aims to develop an age-relevant preclinical in vitro model of human astrocytes to investigate DNA methylation and transcriptional signatures associated with aging and Alzheimer’s disease (AD). The study will validate an “age-in-a-dish” model using direct conversion of adult human fibroblasts to induced-astrocytes (FDIAs), capturing age-related molecular and cellular phenotypes. The project will evaluate the relationship between DNA methylation and astrocyte function, contributing to understanding the molecular etiology of age-related brain disorders.