Award
National Heart, Lung, and Blood Institute 5R61HL175687-02
Cobinamide as a disease-modifying treatment for Marfan Syndrome: optimization of absorption
Recipient
University of California, San Diego
Award Amount
$393,883.00
Ceiling
$393,883.00
Awarded
May 14, 2026
Identifier
5R61HL175687-02
The award supports research to enhance oral absorption of cobinamide to treat Marfan Syndrome by modifying ligands and using permeation enhancers, aiming for improved bioavailability and disease-modifying treatment.
Description
This project focuses on increasing the bioavailability of cobinamide, a potential treatment for Marfan Syndrome, through chemical modification and formulation strategies to improve absorption and permeation, ultimately aiming for a practical long-term therapy.