Award
National Institute on Aging 1R03AG081950-01A1
Role of Keratin 18 for Stress-induced Adaptive Strength Gains
Recipient
Ohio University Athens
Award Amount
$151,000.00
Ceiling
$151,000.00
Awarded
September 22, 2023
Identifier
1R03AG081950-01A1
This award funds research on the role of keratin 18 in skeletal muscle adaptation and strength gains, particularly related to aging and sarcopenia, using mouse models.
Description
The project focuses on the role of keratin 18 in muscle strength and aging. It involves in vivo and ex vivo physiological assessments using young, adult, and old mice to understand muscle resilience and potential interventions for sarcopenia and frailty. The study aims to determine if adaptive strength gains following eccentric contractions are mediated by Krt18 in young mice and if age-related loss of Krt18 expression is associated with blunted strength gains.