Award
National Institute of General Medical Sciences 5R35GM139621-05
Control of gene expression by dynamic metabolic oscillations
Recipient
University of California at Davis
Award Amount
$374,264.00
Ceiling
$374,264.00
Awarded
July 04, 2025
Identifier
5R35GM139621-05
NIH grant awarded to University of California at Davis to study the impact of metabolic oscillations on gene expression and cell fate, aiming to understand mechanisms relevant to chronic diseases and drug effects.
Description
This NIH grant project investigates how oscillations in metabolic state drive gene expression programs distinct from static conditions, focusing on transcription factors FOXO3 and TFEB. The study uses live-cell reporters, inducible expression constructs, and mathematical modeling to understand gene expression control and its impact on cell fate decisions related to diseases like cancer, diabetes, and aging. It also evaluates pharmacological inhibitors such as metformin.