# NIH Reporter #5K23HD114892-02

Syphilis in pregnancy: placental histopathology and transcriptomic linkage to outcomes

**Recipient:** UT Southwestern Medical Center

**Award Amount:** $167,383.00
**Ceiling:** $167,383.00

**Awarded:** June 26, 2026

**Identifier:** 5K23HD114892-02

NIH K23 career development award supporting research and training to investigate how syphilis and its treatment affect placental biology and neonatal outcomes, including preterm birth and congenital syphilis.

### Description

The project will characterize Treponema pallidum-driven histopathologic and molecular changes at the maternal-placental-fetal immune interface and link maternal disease and treatment timing, treponemal burden, placental histopathology, and transcriptome profiles with preterm birth and congenital syphilis outcomes.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11377279)