Award
National Institute of Neurological Disorders and Stroke 5R01NS118026-06
Mammalian Target of Rapamycin Signaling and the Suprachiamatic Circadian Clock
Recipient
Rutgers Biomedical and Health Sciences
Award Amount
$357,882.00
Ceiling
$357,882.00
Awarded
July 19, 2024
Identifier
5R01NS118026-06
Research project funded by the National Institute of Neurological Disorders and Stroke to study the role of mTOR signaling in the brain's circadian clock, aiming to understand its impact on circadian regulation and related neurological disorders.
Description
The objective of the proposed research is to understand physiological functions of the mammalian target of rapamycin (mTOR) signaling pathway in the brain circadian (~24 h) clock, the hypothalamic suprachiamatic nucleus (SCN). The research aims to elucidate fundamental mechanisms whereby mTOR regulates the function of the circadian clock, with implications for neurological and psychiatric diseases associated with disrupted rhythms and sleep problems. The project involves genetic and pharmacological manipulation of mTOR pathways and aims to contribute significant new knowledge about circadian regulation and sleep disorders.