Award
NIH Reporter #5R03NS145171-02
Development of Knockin Mouse Models for Study of a Novel Alpha-Synuclein Phosphorylation Site
Recipient
Yale University
Award Amount
$84,000.00
Ceiling
$84,000.00
Awarded
July 17, 2026
Identifier
5R03NS145171-02
This award funds the development of phospho-null and phospho-mimetic knock-in mouse models to study the physiological and pathological roles of a novel phosphorylation site on α-synuclein relevant to synucleinopathies such as Multiple Systems Atrophy.
Description
The project involves developing and characterizing genetically modified mouse models to study the role of specific post-translational modifications of α-synuclein. The research aims to elucidate mechanisms underlying synucleinopathies and synaptic function. The project is funded by NIH grant PA-20-200.