Award
National Cancer Institute 1F30CA306319-01
Dissecting a novel role of FAK in modulating immunity during metastatic reactivation and progression
Recipient
Columbia University Health Sciences
Award Amount
$51,492.00
Ceiling
$51,492.00
Awarded
July 17, 2025
Identifier
1F30CA306319-01
A research project funded by the National Cancer Institute to study the role of FAK in immune regulation during cancer metastasis, aiming to develop new immunotherapeutic approaches.
Description
This project aims to dissect the role of focal adhesion kinase (FAK) in immune regulation during metastasis reactivation, with potential therapeutic implications. The project investigates how FAK influences immune evasion and metastatic reactivation, focusing on its interaction with IRF3 and the STING pathway. It involves genetic validation, mechanistic studies, and testing of therapeutic strategies. Research goals include determining the impact of Fak:Irf3 interaction on metastasis and testing whether Fak depletion enhances immunotherapy response.