Award
National Institute of Allergy and Infectious Diseases 5R01AI179741-03
Non-Templated Regulation of IgE Mediated Anaphylaxis
Recipient
Massachusetts General Hospital
Award Amount
$830,746.00
Ceiling
$830,746.00
Awarded
December 02, 2025
Identifier
5R01AI179741-03
The award supports research to investigate how the glycosylation of IgE antibodies affects allergic responses, with the goal of identifying new therapeutic targets for allergy treatment.
Description
This project aims to understand how glycosylation of antibodies, specifically the removal of sialic acid from IgE, regulates immune responses and attenuates allergic reactions. The research combines biophysics, biochemistry, cellular and molecular immunology, and glycobiology to identify novel pathways regulating allergic disease and potential therapeutic targets.