Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK134706-04
Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Recipient
University of Colorado Denver
Award Amount
$623,365.00
Ceiling
$623,365.00
Awarded
June 17, 2026
Identifier
5R01DK134706-04
Research project funded by NIDDK to study how weight loss affects IMAT signaling and its impact on muscle insulin sensitivity and inflammation, relevant to type 2 diabetes risk.
Description
This project aims to determine the impact of weight loss on intermuscular adipose tissue (IMAT) secretion of fibronectin, inflammatory cytokines, and eicosanoids, and how these factors influence muscle insulin sensitivity and inflammation. The research involves ultrasound-guided IMAT biopsies, MRI measurements, insulin clamps, and in vitro experiments to evaluate changes before and after a 12-week weight loss intervention.