Award
National Institute on Aging 1R21AG089974-01A1
The role of mitochondrial deficits in tauopathy-linked autophagy defects
Recipient
Rutgers, The State University of New Jersey, Piscataway, NJ
Award Amount
$431,750.00
Ceiling
$431,750.00
Awarded
May 20, 2025
Identifier
1R21AG089974-01A1
Research project funded by the National Institute on Aging to study how mitochondrial dysfunction contributes to autophagy defects in tauopathy, aiming to improve understanding and treatment of Alzheimer's disease-related tau pathology.
Description
This project investigates the mechanisms by which mitochondrial deficits affect autophagy defects linked to tauopathy, focusing on the role of Mitochondrial Rho GTPase (Miro) in enhancing mitochondrial phosphatidylethanolamine (PE) biosynthesis to rescue autophagy deficits and alleviate tau pathology and cognitive deficits in tauopathy mice.