Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD087417-10
Molecular basis of MED12 in the pathogenesis of uterine fibroids
Recipient
University of Texas Health Science Center, San Antonio, TX
Award Amount
$363,682.00
Ceiling
$363,682.00
Awarded
May 01, 2026
Identifier
5R01HD087417-10
The award supports research on how MED12 mutations drive uterine fibroid formation through stem cell reprogramming and replication stress, with the goal of developing non-hormonal treatments.
Description
This project investigates the molecular mechanisms by which MED12 mutations contribute to the development of uterine fibroids, focusing on aberrant myometrial stem cell differentiation and replication stress. It aims to elucidate the biochemical basis of kinase disruption, link it to tumor initiation, and evaluate potential therapeutic interventions using ATR axis inhibitors in a preclinical mouse model.