Award
NIH Reporter #1R21NS140780-01A1
Utilizing CNS tissue derived extracellular vesicles to identify biomarkers of remyelination and demyelination
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$427,104.00
Ceiling
$427,104.00
Awarded
September 23, 2025
Identifier
1R21NS140780-01A1
The award supports research to discover biomarkers for demyelination and remyelination in multiple sclerosis using extracellular vesicles from CNS tissue and plasma, facilitating the development of treatments promoting myelin repair.
Description
This project aims to identify novel biomarkers of demyelination and remyelination in multiple sclerosis by studying altered proteins and lipids in tissue-derived and plasma-derived extracellular vesicles (EVs) in a mouse model of demyelination. The research uses proteomics analyses to profile EVs isolated from mouse or human tissue to find meaningful biomarkers of the disease process, with the goal of promoting therapeutic strategies for repair and remyelination in MS.