Award
National Cancer Institute 5F31CA288017-03
Elucidating the Role of AIRE and Tumor Associated Aire-expressing Cells in Tumor Growth and Immune Evasion
Recipient
University of California, San Francisco
Award Amount
$42,633.00
Ceiling
$42,633.00
Awarded
March 04, 2026
Identifier
5F31CA288017-03
NIH/NCI awarded $42,633 to University of California, San Francisco for research on the role of AIRE and tumor-associated Aire-expressing cells in tumor growth and immune evasion, aiming to understand their function and identify therapeutic targets.
Description
This research project funded by NIH/NCI focuses on tumor immunology and the function of the AIRE gene. It aims to define the phenotypic and transcriptional profiles of tumor-associated extrathymic Aire-expressing cells (eTACs), investigate mechanisms by which Aire+ cells promote tumor growth, and elucidate signals driving Aire expression using methods like single-cell RNA-seq, CyTOF, flow cytometry, and in vivo mouse models.