Award
National Institute of General Medical Sciences 5R35GM144241-05
Novel functions for Sm-class RNAs in the regulation of gene expression
Recipient
University of Utah, Salt Lake City, UT
Award Amount
$385,000.00
Ceiling
$385,000.00
Awarded
January 19, 2026
Identifier
5R35GM144241-05
A multi-year NIH-funded research project investigating the roles of Sm-class RNAs and viral ncRNAs in gene regulation and viral oncogenesis using herpesvirus models.
Description
This project studies the novel functions of particles composed of Sm proteins and small nuclear RNAs of viral and cellular origin, aiming to understand their contribution to cancers of viral origin and cellular homeostasis. The research involves genetic, genome-wide, molecular biology, and biochemical approaches to characterize the mechanisms of snRNA functions, especially focusing on viral ncRNAs (HSURs) in herpesvirus-infected cells and their role in gene regulation.