# NIH Reporter #1K99AI199380-01

Defining CD4+ T Cells Driving Protection and Susceptibility in Helminth Reinfection

**Recipient:** UT Southwestern Medical Center

**Award Amount:** $192,369.00
**Ceiling:** $192,369.00

**Awarded:** September 01, 2026

**Identifier:** 1K99AI199380-01

The project investigates immune mechanisms underlying protection and persistent susceptibility to hookworm reinfection, with the goal of informing prevention, diagnosis, and treatment of parasitic and inflammatory diseases.

### Description

K99/R00 research project studying CD4+ T-cell populations involved in protection against hookworm and how chronic infection alters their composition and function, using a rodent model and blood cells from adults with hookworm infection.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11352139)