Award
National Institute of Allergy and Infectious Diseases 5K08AI182474-03
Harnessing machine learning to develop new antibiotics for Neisseria gonorrhoeae
Recipient
Massachusetts General Hospital
Award Amount
$196,738.00
Ceiling
$196,738.00
Awarded
February 12, 2026
Identifier
5K08AI182474-03
This project leverages machine learning to accelerate the discovery of new antibiotics against drug-resistant Neisseria gonorrhoeae, addressing a critical public health threat.
Description
This project aims to apply machine learning techniques, such as graph neural networks, to identify new antibiotic candidates for Neisseria gonorrhoeae by predicting growth inhibitory activity from chemical structures. The research builds on previous screening of 38,000 compounds and plans to screen large chemical libraries in silico, validate in vitro, determine mechanisms of action, and test in vivo efficacy.