Award
National Institute of Allergy and Infectious Diseases 5R01AI187178-02
Curing chronic Toxoplasma infection with novel and potent protease inhibitors
Recipient
University of Michigan at Ann Arbor
Award Amount
$616,867.00
Ceiling
$616,867.00
Awarded
July 23, 2026
Identifier
5R01AI187178-02
This NIH grant supports research to develop novel protease inhibitors to cure chronic Toxoplasma gondii infection by targeting a key lysosomal protease, with the goal of eradicating infection in mouse models.
Description
Focuses on developing drugs to cure chronic Toxoplasma gondii infection, targeting lysosomal protease TgCPL, with aims to develop structure-to-function models, optimize inhibitors, and eradicate infection in mouse models.