Award
National Institute of Allergy and Infectious Diseases 1R56AI183675-01A1
Use of probiotics to modulate antimicrobial peptide signaling in the neonatal innate immune response to influenza virus
Recipient
Drexel University
Award Amount
$554,786.00
Ceiling
$554,786.00
Awarded
September 16, 2025
Identifier
1R56AI183675-01A1
Research project funded by NIH to study the effect of probiotics on neonatal immune response to influenza virus, focusing on antimicrobial peptide signaling and immune cell activation.
Description
This project investigates how probiotics, specifically Lactobacillus rhamnosus (LGG), influence the immune response in neonatal mice infected with influenza virus. It aims to understand the mechanisms by which LGG modulates antimicrobial peptide signaling, particularly focusing on CRAMP production and its role in alveolar macrophage activation and neutrophil recruitment.