# NIH Reporter #1F31CA318731-01

LARP1-Driven Control of Ribosomal Biogenesis Alters Translation in CAR T cells

**Recipient:** University of Pennsylvania

**Award Amount:** $50,114.00
**Ceiling:** $50,114.00

**Awarded:** July 29, 2026

**Identifier:** 1F31CA318731-01

The project studies LARP1’s role in controlling ribosomal biogenesis and translation in CAR T cells, and evaluates whether deleting LARP1 can improve CAR T cell persistence and antitumor activity.

### Description

Research project investigating how the RNA-binding protein LARP1 regulates ribosomal biogenesis, translation, CAR T cell persistence, and antitumor activity.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11464217)