Award
National Institute on Aging 1R21AG091650-01
Does GLUT5-mediated Fructose Metabolism drive Microglial Dysfunction in Aging and Alzheimer's Disease?
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$442,104.00
Ceiling
$442,104.00
Awarded
September 26, 2024
Identifier
1R21AG091650-01
This NIH-funded research project aims to study how fructose metabolism through GLUT5 affects microglial dysfunction in Alzheimer's disease, developing genetic tools and testing interventions to inhibit fructose metabolism as a therapeutic approach.
Description
The project investigates the role of fructose metabolism, specifically via the transporter GLUT5, in microglial dysfunction related to Alzheimer's disease. It hypothesizes that limiting fructose metabolism may improve microglial function and halt disease progression.