Award
National Heart, Lung, and Blood Institute 5K23HL173709-03
A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock
Recipient
Boston University Medical Campus
Award Amount
$169,452.00
Ceiling
$169,452.00
Awarded
July 31, 2026
Identifier
5K23HL173709-03
The award supports research to improve blood transfusion effectiveness during septic shock by analyzing current practices, identifying patient-specific treatment effects, and piloting a decision aid in a hospital ICU setting.
Description
This project aims to benchmark hemoglobin threshold-based blood transfusion practices across U.S. hospitals, identify patient heterogeneity in treatment effects, and pilot an evidence-informed transfusion decision aid in the Boston Medical Center ICU. The research employs econometric and causal inference techniques to fill knowledge gaps, improve clinical practice, and inform future clinical trials related to blood transfusions in septic shock patients.