Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR080416-05
ENPP1 regulation of mammalian bone mass
Recipient
Yale University, New Haven, CT
Award Amount
$467,971.00
Ceiling
$467,971.00
Awarded
May 19, 2026
Identifier
5R01AR080416-05
Research project funded by NIAMS to study ENPP1's role in bone mass regulation and develop therapeutic approaches for related bone disorders using novel animal models and biologics.
Description
The proposed research aims to identify pathways and mechanisms by which ENPP1 induces low bone mass and explore therapeutic approaches for paradoxical mineralization states. The study will investigate signaling pathways, both catalytically dependent and independent, regulating bone mass, using novel animal models and proprietary biologics. The research addresses critical gaps in understanding disorders like hereditary osteoporosis and CKD-MBD.