Award
National Heart, Lung, and Blood Institute 5R01HL176663-02
Investigating the pro-regenerative potential of Pontin in the heart
Recipient
Boston Children's Hospital
Award Amount
$816,922.00
Ceiling
$816,922.00
Awarded
August 06, 2026
Identifier
5R01HL176663-02
A federal NIH grant awarded to Boston Children's Hospital to study the role of Pontin in heart regeneration, aiming to develop gene therapy strategies for cardiac repair.
Description
This project aims to expand understanding of the gene regulatory networks controlling cardiomyocyte proliferation, focusing on the AAA+ ATPase Pontin. The research involves mechanistic studies in zebrafish and mice to identify how Pontin influences heart regeneration, with the goal of developing strategies to stimulate heart repair in humans.