Award
National Cancer Institute 5R01CA262788-05
Targeting of Doppel-axis to Control Lung Tumor Angiogenesis and Immunity
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$352,275.00
Ceiling
$352,275.00
Awarded
June 05, 2026
Identifier
5R01CA262788-05
Research project focused on targeting the doppel protein to control lung tumor angiogenesis and immunity, developing monoclonal antibodies to inhibit tumor growth and immune suppression.
Description
This project aims to establish doppel as a new target in tumor angiogenesis, causing tumors to develop their own vascular networks, create an immunosuppressive microenvironment, and grow. The project will develop drugs to specifically block doppel activity in tumors while minimizing side effects of existing anti-angiogenic drugs.