Award
NIH Reporter #1R21ES037418-01A1
Placental Serotonin: A Potential Mediator of Dieldrin-Related Neurotoxicity and the Developmental Origins of Parkinson’s Disease Risk
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, USA
Award Amount
$422,117.00
Ceiling
$422,117.00
Awarded
February 19, 2026
Identifier
1R21ES037418-01A1
NIH funded research project studying how placental serotonin disruption by pesticide dieldrin may mediate developmental neurotoxicity and increase Parkinson’s disease risk.
Description
This project investigates the role of placental serotonin (5HT) disruption as an indirect mechanism of developmental neurotoxicity (DNT) related to exposure to the pesticide dieldrin. The study aims to test two hypotheses: Aim 1: Dieldrin affects monoaminergic systems within the placenta, disrupting placental 5HT, which may serve as an additional indirect mechanism of DNT. Aim 2: Developmental exposure to dieldrin alters the development of fetal and neonatal monoamine systems. The research has implications for understanding how environmental toxicants contribute to neurodevelopmental disorders and diseases such as Parkinson’s disease.