Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB032726-04
Engineered BacNav and BacCav for Improved Excitability and Contraction
Recipient
Duke University, Durham, NC
Award Amount
$477,473.00
Ceiling
$477,473.00
Awarded
January 15, 2025
Identifier
5R01EB032726-04
The award supports research to develop AAV-based gene therapies using engineered BacNav and BacCav channels to enhance cardiomyocyte excitability and contractility, potentially preventing sudden cardiac death and heart failure progression.
Description
This project aims to develop new gene therapies employing engineered prokaryotic sodium and calcium channels to improve electrical and mechanical function of the heart, tested in mouse models of disease.