Award
National Institute on Aging 5R01AG080565-03
Brain mitochondrial PET imaging and 31P-MR spectroscopy to dissect the role of mitochondrial dysfunction in bioenergetic dysregulation in Dementia with Lewy Bodies pathogenesis
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$1,679,694.00
Ceiling
$1,679,694.00
Awarded
July 16, 2025
Identifier
5R01AG080565-03
The award funds a research project using advanced brain imaging techniques to study mitochondrial and bioenergetic dysfunction in Dementia with Lewy Bodies, aiming to understand disease mechanisms and develop targeted therapies.
Description
This study aims to elucidate the patterns and mechanisms of bioenergetic dysfunction, such as mitochondrial respiratory dysfunction, glycolytic failure, or failure of energy reserves in vivo, using advanced neuroimaging techniques including PET radioligands for mitochondrial Complex I, FDG-PET for glycolytic energy metabolism, and 7T 31P-MRS for ATP assessment. The study will evaluate mitochondrial and bioenergetic contributions across the clinical spectrum of Dementia with Lewy Bodies (DLB), characterize mitochondrial dysfunction progression, dissect bioenergetic pathways, analyze relationships with cognitive and peripheral measures, and compare dysfunction between DLB and Alzheimer’s disease.