Award
National Heart, Lung, and Blood Institute 1R01HL180413-01A1
Preclinical evaluation of the performance of a cell free tissue engineered vascular graft
Recipient
Research Institute Nationwide Children's Hospital, Columbus, OH, United States
Award Amount
$775,114.00
Ceiling
$775,114.00
Awarded
June 16, 2026
Identifier
1R01HL180413-01A1
This NIH-funded project focuses on developing a cell-free tissue engineered vascular graft for congenital heart surgery, aiming to improve clinical outcomes by comparing different graft types in a preclinical ovine model.
Description
The project aims to develop and evaluate a cell-free tissue engineered vascular graft (TEVG) for congenital heart surgery. The TEVG is designed to perform similarly or better than autologous tissue and prosthetic biomaterials, with the potential to grow and reduce complications. The study will compare the performance of cell-free, seeded, and unseeded TEVGs in an ovine model, assessing inflammation, compliance, and calcification over time.