Award
NIH Reporter #2P01AG049665-11A1
Disordered Proteostasis as a Driver of Disease in the Aging Lung
Recipient
Northwestern University
Award Amount
$2,999,872.00
Ceiling
$2,999,872.00
Awarded
August 18, 2026
Identifier
2P01AG049665-11A1
NIH grant awarded to Northwestern University to study aging-related lung disease mechanisms and interventions, focusing on proteostasis, mitochondrial dysfunction, and inflammation.
Description
This project aims to understand biologic changes with aging that increase susceptibility to pneumonia and its sequelae, focusing on stress pathways, mitochondrial dysfunction, and inflammation in the aging lung and brain. The research involves multi-omic analysis of cells and tissues from mouse models and patients, with the goal of identifying interventions to improve lifespan and healthspan in the elderly.