Award
National Institute of Neurological Disorders and Stroke 1RF1NS136108-01
Cellular Mechanisms and Therapeutic Potential of NR4A1 in Pain Resolution
Recipient
National Institute of Neurological Disorders and Stroke (NINDS)
Award Amount
$2,103,564.00
Ceiling
$2,103,564.00
Awarded
May 28, 2024
Identifier
1RF1NS136108-01
This NIH/NINDS funded project focuses on understanding and leveraging NR4A1's role in pain resolution to develop new therapies for postoperative and low back pain, including biomarker identification and drug evaluation.
Description
The project investigates the role of NR4A1 in pain resolution and aims to validate NR4A1 as a therapeutic target for postoperative pain and low back pain. It also seeks to identify SPP1 as a biomarker for pain resolution. The project is funded by the NIH/NINDS and is part of the HEAL initiative. It involves multiple specific aims, including testing the role of NR4A1 in macrophages, evaluating FDA-approved NR4A1 agonists, and studying the regulation of SPP1. The project emphasizes translational research with potential clinical implications for pain management and opioid misuse prevention.