VA San Diego Healthcare System 11206908

BCCMA: VA Colorectal Cancer Clinical & Computational Collaborative (VA-5C): NIR-labeled antibodies to target and label colon polyps and cancer for improved diagnosis and surgery

Award for developing near-infrared fluorescence labeling techniques to improve diagnosis and surgery of colorectal cancer.

Description

This project aims to develop tumor-specific near-infrared fluorescence labeling of premalignant polyps and colorectal cancer using genetically engineered mouse models and patient-derived orthotopic xenograft models. The goal is to improve diagnosis and surgical outcomes for colorectal cancer, with potential clinical development of fluorescent anti-mucin antibody-based fluorescence-guided surgery.

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