Award
NIH Reporter #1R01NS144145-01A1
Sex-specific role of GABA signaling in glioblastoma immune response
Recipient
University of Miami School of Medicine
Award Amount
$575,453.00
Ceiling
$575,453.00
Awarded
September 01, 2026
Identifier
1R01NS144145-01A1
NIH grant awarded to University of Miami School of Medicine to study sex-specific GABA signaling effects on glioblastoma immune response and metabolism in myeloid-derived suppressor cells.
Description
This project aims to investigate the sex-specific mechanisms by which gamma-aminobutyric acid (GABA) influences glioblastoma (GBM) immune response, focusing on the modulation of arginine metabolism in myeloid-derived suppressor cells (MDSCs). The research will explore how GABA signaling affects tumor microenvironment interactions and immune suppression in a sex-dependent manner, with potential implications for targeted immunotherapy.