Award
NIH Reporter #1ZIAHD000196-28
Phosphoinositide-calcium Signaling In Cell Regulation
Recipient
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Award Amount
$2,241,746.00
Ceiling
$2,241,746.00
Awarded
April 27, 2024
Identifier
1ZIAHD000196-28
This award supports research on cellular membrane organization and lipid signaling pathways, aiming to understand molecular mechanisms critical for cell regulation and disease, including the development of molecular tools to study phosphatidylinositol 3,5-bisphosphate and its role in cellular functions.
Description
Research focused on how cells organize their internal membranes to provide a structural framework for molecular signaling complexes, ensuring proper information processing. The project involves creating molecular tools to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate, studying sorting nexin 10's role in lysosomal ionic homeostasis, and understanding plasma membrane recruitment of PI4KA by EFR3. The research has implications for human diseases and viral infections.