Award
NIH Reporter #5U01AI158460-05
Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab
Recipient
University of Texas Health Science Center
Award Amount
$1,183,478.00
Ceiling
$1,183,478.00
Awarded
May 12, 2026
Identifier
5U01AI158460-05
This award funds a clinical trial investigating the effects of dupilumab on allergic asthma and rhinitis, focusing on disease severity and treatment response.
Description
A 22-week clinical trial using an aeroallergen challenge chamber to evaluate the effects of dupilumab on allergic asthma and rhinitis. The study aims to understand heterogeneity in disease severity and treatment response related to epithelial integrity and inflammation.