Award
National Institute of General Medical Sciences 5R01GM124143-09
Nuclear Pore Complexes As Scaffolds For Genome Architecture And Epigenetic Maintenance
Recipient
San Diego State University
Award Amount
$325,532.00
Ceiling
$325,532.00
Awarded
August 19, 2025
Identifier
5R01GM124143-09
This award funds research on Nuclear Pore Complex components to understand their role in genome organization and gene regulation, with implications for tissue development and disease.
Description
The project investigates the role of Nuclear Pore Complex (NPC) components (Nups) in tissue-specific development and human pathologies, including cardiac disorders and hematologic malignancies. It aims to define molecular mechanisms by which Nups organize the genome and regulate gene expression, focusing on their function as scaffolds for genome organization and their role in enhancer-promoter looping, transcriptional memory, and epigenetic maintenance.