Award
National Institute of General Medical Sciences 5P30GM124165-09
MX Core
Recipient
Cornell University
Award Amount
$2,066,815.00
Ceiling
$2,066,815.00
Awarded
May 20, 2026
Identifier
5P30GM124165-09
The MX Core project at Cornell University operates advanced beamlines for macromolecular crystallography, providing 24/7 user access and maintaining state-of-the-art facilities. It supports high-speed data collection and plans upgrades to enhance capabilities including serial microcrystallography and automated data collection.
Description
NE-CAT operates two mature, state-of-the-art beamlines optimized for macromolecular crystallography at the APS. The goal of the Macromolecular Crystallography (MX) Core is to provide user access to these facilities, maintain the facilities, and make improvements to remain state-of-the-art. The core provides 24/7 access, on-site or on-call, for both on-site and remote users, supporting high-speed data collection, crystal screening, SAD/MAD phasing, molecular replacement, and methods for challenging crystals. It maintains hardware and software, including beamline optics, computing infrastructure, and RAPD software, with plans for upgrades compatible with the APS upgrade scheduled for 2023. The project aims to develop methodologies for serial microcrystallography and fully automated crystal screening and data collection.