Award
NIH Reporter #5K08HL178490-02
The dynamic role of the alveolar macrophage during pulmonary bacterial infection
Recipient
University of Washington
Award Amount
$161,890.00
Ceiling
$161,890.00
Awarded
September 01, 2026
Identifier
5K08HL178490-02
NIH funded research project studying alveolar macrophages' role in pulmonary bacterial infections to improve host defense strategies, focusing on Burkholderia pseudomallei.
Description
This project aims to delineate the role of alveolar macrophages in bacterial pulmonary infections, focusing on their innate immune functions during early infection and recovery. The research involves in vivo and in vitro studies using murine models, immunomodulatory polymers, and chimeric mouse models to understand host-pathogen interactions, especially concerning Burkholderia pseudomallei, a Tier 1 Select Agent.