Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK142423-03
Alpha- to Beta-Cell Communication in Health and Disease
Recipient
Duke University, Durham, NC
Award Amount
$681,890.00
Ceiling
$681,890.00
Awarded
June 25, 2026
Identifier
5R01DK142423-03
Research project funded by NIDDK to study alpha to beta cell communication and its role in diabetes, involving preclinical and clinical studies at Duke University.
Description
This project aims to investigate the complex role of α-cells in glucagon secretion and its impact on β-cell function and glucose tolerance, focusing on preclinical studies of human islets and translational studies in human subjects. The research explores mechanisms of α- to β-cell communication, proglucagon peptide processing, and implications for type 2 diabetes pathogenesis and treatment.