Award
National Cancer Institute 1R01CA308771-01A1
Role of tumor biomechanics on drug-receptor engagement
Recipient
Albany Medical College
Award Amount
$648,579.00
Ceiling
$648,579.00
Awarded
June 03, 2026
Identifier
1R01CA308771-01A1
NIH grant awarded to Albany Medical College to develop a multimodal imaging system to study tumor biomechanics and its effect on drug delivery and efficacy, aiming to improve therapies for HER2-positive breast cancers.
Description
This project will develop and apply an innovative multimodal imaging technology, mFLIO², that uniquely integrates molecular, biomechanical, and structural imaging to quantify how tumor stiffness and vascular organization affect drug delivery and new interventions to mitigate its impact on therapeutic response. By identifying how tumor microenvironment mechanics regulate antibody accessibility, this research will advance precision strategies to overcome resistance and improve outcomes for patients with HER2-positive cancers.